Back to the Top
Dear List Members,
As well the majority aspects of allometry came from the evolutionary
paradigm, i.e. there is the term "evolutionary allometry" (comparative
analysis of populations/species), I wonder if anybody knows about the
use and development of the knowledge area under the term "evolutionary
pharmacokinetics". That would represent the understanding of the
current human pharmacokinetics of drugs/medicines under the
evolutionary or Darwinian perspective.
Some publications have pointed closely to this concept ("evolutionary
pharmacokinetics"), as Boxenbaum's review "Interspecies pharmacokinetic
scaling and the evolutionary-comparative paradigm" dated on 1984; but
does anybody know about a current and direct look to that concept,
"evolutionary pharmacokinetics"?
Thanks in advance,
Candido Hernandez-Lopez
Esteve Group, Spain
Back to the Top
Candido,
You may want to look at a series of Science papers on derivations
relating
to these relationships. The citations are:
1. West GB et al. A general model for the origin of allometric scaling
laws
in biology. Science 1997;276:5309:122-126
2.West GB et al. The fourth dimension of life: fractal geometry and
allometric scaling or organisms. Science. 1999;284:5420:1677-1679.
3.Gillooly JF et al. Effects of size and temperature on metabolic rate.
Science 2001;293:5538:2248-2251.
Regards,
Rob Bies
University of Pittsburgh
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)