PharmPK Discussion - Factors for allometric scaling

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On 12 Nov 2004 at 14:19:21, "Yilong Zhang" (Yilong.Zhang.-a-.ipi.com) sent the message


Dear all,
Can any one provide a reference for allometric scaling factors? I need
to know the hepatic blood flow rate and maximum life span for mouse,
rat, monkey and human.
Thanks.
Yilong Zhang, Ph.D.
Infinity Pharmaceuticals, Inc.
780 Memorial Drive
Cambride, MA 02139
Phone: 617-453-1265
Fax: 617-453-1001
Email: Yilong.Zhang.-at-.ipi.com

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On 15 Nov 2004 at 10:09:53, "Siddiqui, M. Asif Ali" (M.AsifAli.Siddiqui.-at-.adis.co.nz) sent the message


Hi Zhang,
Here're a couple of references I came across on scaling. Hope they're
useful.
Mahmood I, Balian JD. The pharmacokinetic principles behind scaling from
preclinical results to phase I protocols. Clin Pharmacokinet. 1999
Jan;36(1):1-11.
Lave T, Coassolo P, Reigner B. Prediction of hepatic metabolic clearance
based on interspecies allometric scaling techniques and in vitro-in vivo
correlations. Clin Pharmacokinet. 1999 Mar;36(3):211-31.
Cheers!
Asif Siddiqui

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On 16 Nov 2004 at 13:51:26, varun goel (varun_goel_9.at.yahoo.com) sent the message


Hi Yilong,
You may find following references helpful.
Interspecies Scaling, Allometry, and the Ground plan of
Pharmacokinetics.
J Pharmacokinetic Biopharmaceutics, vol 10, No-2, 1982.
Interspecies Pharmacokinetic Scaling and the evolutionary-comparative
paradigm.
Drug Metabolism reviews, 15 (5&6), 1071-1121 (1984)
Interspecies pharmacokinetic scaling and the Dedrick plots.
Auth: Harold Boxenbaum and Robert Ronfeld
Hope this helps
Varun Goel,
Graduate student
Massachusetts College of Pharmacy
Boston, MA, 02120
Phone-617-735-1096

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On 21 Nov 2004 at 05:17:00, "hamishehkar" (hamishehkar.-a-.pharm.mui.ac.ir) sent the message


Dear Yilong,
Review these articles. I hope those would be useful.
Journal of pharmaceutical sciences (1986) 75(11): 1028-1040
You can find the hepatic blood flow rate of rat here:
Pharmaceutical Research (1994) 11(7): 945-950
  Maximum life span: Journal of pharmaceutical sciences (1986) 75(11):
1053-
1062
Sincerely,
Hamed Hamishehkar	
Department of Pharmaceutics
Faculty of Pharmacy and pharmaceutical sciences
Isfahan University of Medical Sciences
Isfahan, Iran

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