- On 4 Nov 2004 at 17:13:06, Navdeep Randhawa (Navdeep.Randhawa.-a-.biovail.com) sent the message

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Hello,

I just came across a slightly different format for the formula for

calculating intrasubject CV for BE studies [CV = 100 * sqrt(MSE)]. Has

anyone used this formula for sample size calculations? Also, if someone

can

share their experience on the standard formula for calculating

intrasubject

CV?

Many thanks,

Nav - On 5 Nov 2004 at 09:36:58, vallix.-a-.virbac.fr sent the message

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Hi,

The formula I used to calculated intra-individual variation in

bioequivalence study is :

CV = intra-individual coefficient of variation, CV = sqrt

([exp(s2r)-1]) with

s2r = residual variance

I hope this will help,

Virginie ALLIX

Pharmacokineticist, Pharmacologist

VIRBAC R&D

BP 27

06511 CARROS CEDEX

FRANCE

Tel. +33 (0)4 92 08 70 18

Fax. +33 (0)4 92 08 77 38

Email. vallix.at.virbac.fr

http://www.virbac.com

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