PharmPK Discussion - Formula for calculating Intrasubject CV

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On 4 Nov 2004 at 17:13:06, Navdeep Randhawa (Navdeep.Randhawa.-a-.biovail.com) sent the message


Hello,
I just came across a slightly different format for the formula for
calculating intrasubject CV for BE studies [CV = 100 * sqrt(MSE)]. Has
anyone used this formula for sample size calculations? Also, if someone
can
share their experience on the standard formula for calculating
intrasubject
CV?
Many thanks,
Nav

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On 5 Nov 2004 at 09:36:58, vallix.-a-.virbac.fr sent the message


Hi,
The formula I used to calculated intra-individual variation in
bioequivalence study is :
CV  =  intra-individual  coefficient of variation, CV = sqrt
([exp(s2r)-1]) with
s2r = residual variance
I hope this will help,
Virginie ALLIX
Pharmacokineticist, Pharmacologist
VIRBAC R&D
BP 27
06511 CARROS CEDEX
FRANCE
Tel. +33 (0)4 92 08 70 18
Fax. +33 (0)4 92 08 77 38
Email. vallix.at.virbac.fr
http://www.virbac.com

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