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I would like to ask if you could post the following query:
We have data from two patients suffering from leukemia who received
high dosage therapy with methotrexat. Because of resulting toxic
concentrations hemodialysis was performed twice within 3 days. Plasma
concentrations were measured over 72 h before, during and after
hemodialysis procedures.
I would like to set up a (WinNonlin based) model to analyse the data
and my question to the experts is, if someone knows about WinNonlin
code suitable for this problem. Before inventing the wheel again it
might be helpful to ask for this support.
Any support or comments are highly appreciated.
Thank you
Dieter Hafner
+ Dipl.-Math.Dr.Dieter Hafner + Tel. : +49-211-81-12449 +
+ Institut fuer Pharmakologie + Fax. : +49-211-81-14781 +
+ und klinische Pharmakologie + +
+ Heinrich-Heine-Universitaet + +
+ Moorenstr.5 + email: +
+ D-40225 Duesseldorf + hafner.-a-.uni-duesseldorf.de +
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