PharmPK Discussion - Hemolysis

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On 26 Mar 2004 at 16:39:31, "mahesh jadhav" (maheshgjadhav.-at-.hotmail.com) sent the message


Dear Sir,
I would like to know whether hemolysis of blood occurs after the
treatment of any drug or before any treatment. If blood get hemolysed
after the administration of the drug, there is one possibility that
drug itself has property to lyse the red blood cells.
	If you are collecting the blood to get serum, the moisture or even a
small drop of water in the tube will lyse the blood cells. Secondly, if
you are collecting plasma of the blood then concentration of
anticoagulant should be proper. In our lab, we use 1.5 mg of EDTA
(dipotassium salt) for 1 ml of blood, which gives us the clear plasma.
With Best Regards,
Mahesh Jadhav
Bharat Serums and Vaccines Ltd, Thane, Maharashtra, India
PH- 91-22-25821399/25822181 Ext 252
Fax  91-22-25823640

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On 26 Mar 2004 at 21:55:55, "kiran shankar lagu" (kiranlagu.-at-.rediffmail.com) sent the message

Dear Mahesh ,
You are talking about two different things? Property of drug to
haemolyse presuming isotonic environment,and coagulation in vitro as a
result of tonicity change?
Regards
Kiran

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