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Doing In Vivo pharmacological testing in Drug Discovery can be quite a
challenging task, when you are working with compounds exhibiting very
hepatic clearances, resulting in e.g. lack of exposure, formation of
pharmacological active metabolites etc. Does anybody have experience in
using hepatectomy on rats and mice to decrease the metabolic clearance.
it work? Any hints on the timing of experiments, how fast do they
Thank you in advance.
Klaus G. Jensen
H. Lundbeck A/S
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