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Dear All,
Doing In Vivo pharmacological testing in Drug Discovery can be quite a
challenging task, when you are working with compounds exhibiting very
high
hepatic clearances, resulting in e.g. lack of exposure, formation of
pharmacological active metabolites etc. Does anybody have experience in
using hepatectomy on rats and mice to decrease the metabolic clearance.
Does
it work? Any hints on the timing of experiments, how fast do they
recover
from surgery?
Thank you in advance.
Best regards,
Klaus G. Jensen
H. Lundbeck A/S
KGJ.at.lundbeck.com
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)