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Does anyone know of a way to calculate the AUC for a steady-state dosing
interval without using the trapezoidal method?
Thanks,
Cory
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Cory,
Fit the data to a parametric pharmacokinetic model and estimate
Clearance.
Then AUC=Dose/Interval/Clearance.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
Zealand
email:n.holford.aaa.auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
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Css = Cavg = [(F * Dose)/tau] * 1/CL = AUC/tau
NB: AUC 0-inf following one dose = AUC 0-tau at steady state
All of this is assuming linear kinetics and a PO dose.
Hope this helps.
Burgess B. Freeman III, Pharm.D.
Post-Doctoral Fellow
Department of Pharmaceutical Sciences
St. Jude Children's Research Hospital
332 N. Lauderdale St., MS313, Room D1051
Memphis, TN 38105-2794 USA
E-mail: burgess.freeman.at.stjude.org
Phone: 901-495-2360
Pager: 901-495-3578 Ext. 1972
Fax: 901-525-6869
http://www.stjude.org/pharmaceutical-sciences
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