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Dear All,
I would like to know how to determine if the steady state is reached or
not. Will steady status be determined on the subject basis?
I appreciate your help,
Thanks,
CQ Deng, PhD
PPD Development
[5(+) x terminal half-life and trough levels within some predetermined
difference - db]
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try the iv infusion to get the steady state faster and
easier.
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Hi there,
>...try the iv infusion to get the steady state faster....[Pravin]
This is not entirely correct, time to reach SS is governed by the
clearance and NOT by the input function. However, theoretically
combination of IV bolus and infusion would allow one to achieve SS
immediately in some cases. I don't think it is practically possible
though.
As far as the original question goes, I am not sure what the objective
is but I would start out by
1. making plots (Concentration Vs. Time) for a few subjects
2. Getting references on the route of elimination and elimination
half-life. Then see if the total dosing period was greater than 3
half-lives.
There could be other approaches as well.
Pravin
--
Pravin Jadhav
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Hello,
The number of doses for a given drug to reach steady state is dependent
upon the elimination half-life of the drug and the dosage interval Tau.
From a clinical point of view, the number of doses needed to reach 99 %
of the steady state plasma concentration is equal to 6.6 * elimination
half-life / Tau.
Kind Regards, Renee
Renee Y Hong
Faculty of Pharmacy
University of Sydney
Tel: 61 2 9036 5025
Fax: 61 2 9351 4391
E-mail: yinghong.-at-.pharm.usyd.edu.au
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