Hi All,Back to the Top
I am working on drug permeability by in situ rat gut perfusion
technique. Can I work more than one drug in each experiment? That way
It will be done more faster and need fewer rats. Thanks in advance for
Hi Parvin,Back to the Top
You can estimate in-situ permeability of mixture of drugs (more than
provided you know the absorption pathway of all the drugs in question
by passive diffusion. If any drug is transported actively or is a
for efflux transporters, you cannot combine drugs as that will lead to
saturation of the active processes and is one form of drug-interaction.
Also, even though all the drugs in question are absorbed passively, if
differences in concentration of individual drugs exist, that may
lead to erroneous permeability estimates.
Dear groupBack to the Top
Thank you for all your kind messages. Actually I am doing single pass
intestinal permeability experiments. I need to collect samples about
90-120 min after Canulation.
Hai Parvin,Back to the Top
I think you cannot do that because permeability of one drug may
the other, that way you cannot get the actual transport patterns of the
drugs. There may be also possiblities for drug-drug (PK/PD )
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