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I am into a series of in vitro stability studies (hydrolysis) of esters
in rat liver homogenates (without cofactors) . What I would like to
know is if it is possible from my data to have a gross estimate of
their resistance to hydrolysis in the liver in vivo.
Have in vivo/in vitro relationships like this ever been published?
Iknow that before any estimate Iwill have to includethe oxidative
side of the problem (i.e. cyt p450 involvement).
But I was wondering if anyone might have some useful references on
these in vitro/in vivo relationships.
University di Parma
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