Dear Colleagues,Back to the Top
We plan to perform a study on the absolute Bioavailability of a drug
that is
sparingly soluble in water. Since we ran into major trouble with
getting a
safe and stable i.v. formulation we are thinking about trying an oily
intramuscular injection instead.
Is this a suitable and accepted procedure to determine absolute
bioavailability, and does anyone have experience with this? I would
also be
most grateful for hints on good literature about i.m. administration.
Many Thanks & Best Regards
Christa
Dr. Christa Kneip
Gr\0xB8nenthal GmbH
F & E / Department of Pharmacokinetics
Zieglerstr. 6
D-52078 Aachen, Deutschland
Tel.: +49-(0)241-569-2070
Fax.: +49-(0)241-569-2501
E-mail: christa.kneip.aaa.grunenthal.de
Not recommended as a reference! IMI is just another extravascualarBack to the Top
route of administration, and can give low and variable absorption, in
some cases worse than the oral route. The F (IMI) is affected by type
of muscle, differences in blood circulation at different sites, vehicle
volume, concentration of the injection.
Cheers,
BC
Bruce CHARLES, PhD
Associate Professor and Director,
Australian Centre for Paediatric Pharmacokinetics
School of Pharmacy
The University of Queensland, 4072 Australia
[University Provider Number: 00025B]
TEL: +61 7 336 53194
FAX: +61 7 336 51688
B.Charles.at.pharmacy.uq.edu.au
http://www.uq.edu.au/pharmacy/brucecharles/charles.html
http://www.mater.org.au/pharm/accp.htm
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)