I would like to dose mice with a compound IP. The compound is poorlyBack to the Top
soluble and we've used 1% methyl cellulose to dose PO with this compound in the
past. Are there any toxicity issues with dosing IP with 1% methyl
cellulose or are there worries about the compound becoming available for
absorption from the peritoneal cavity? Can someone suggest another IP formulation that would get the compound into suspension at least? Thank you for your help! -
Maralee McVean, Ph.D.
Senior Scientist, Absorption and Pharmacokinetics
15318 NE 95th St.
Redmond, WA 98052 USA
Phone: 425.895.8666 x 286
We've done IP dosing of 1% MC suspensions.Back to the Top
There should be no problem.
Hai Maraliee,Back to the Top
Carboxy Methyl Cellulose can be used for oral and intraperitoneal
administrations. I think the per centage of CMC (1%) which you have
be high for i.p administrations. The ideal range of CMC per centage for
dosings would be 0.25-0.5%(W/V). If you didn't get uniform suspension
the above mentioned CMC concentrations , you can use DMSO upto 10% for
solubilising your drug and disperse in 0.25 or 0.5% CMC. At higher
concentrations CMC may cause diarrhoea in mice and rats.
I hope I have answered your problem,
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