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I appreciate & acknowledge if someone please provide
me a list of low bioavaialable drugs (preferably new)
with the reason of its low bioavailability.
Thanks & regards
PhD Research Scholar
Dept. of Pharmaceutics,
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I think , it would be diificult for someone to provide a list which
would have all these names. I would probably suggest you to go and
search around feeding key words such as "low bioavailability" and
"poorly or less bioavailable drugs".
Some of the reasons are very obvious and include the chemical
structure, size, charge, pH and partition besides physiological
barriers which may include acidic and intestinal degradation .
Additinally, poor permability for some drugs across the various mucosal
tissues all around on and within the body systems.
Good luck with your quest.
Dear Harmik,Back to the Top
please find attached my suggestion of paper. I think that is not 100%
you are looking for, but it might be usefull.
Molecular Properties of WHO Essential Drugs and Provisional
Nehal A. Kasim, Marc Whitehouse, Chandrasekharan Ramachandran, Marival
Bermejo, Hans Lennern\0x2030s, Ajaz S. Hussain, Hans E. Junginger,# Salomon A.
Stavchansky, Kamal K. Midha, Vinod P. Shah, and Gordon L. Amidon*
in: Molecular Pharmaceutics, 1 (1), 85 -96, 2004
Abstract: The purpose of this study is to provisionally classify, based
the Biopharmaceutics Classification System (BCS), drugs in
immediate-release dosage forms that
appear on the World Health Organization (WHO) Essential Drug List. The
classification in this
report is based on the aqueous solubility of the drugs reported in
commonly available reference
literature and a correlation of human intestinal membrane permeability
for a set of 29
reference drugs with their calculated partition coefficients. The WHO
Essential Drug List consists of
a total of 325 medicines and 260 drugs, of which 123 are oral drugs in
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