Hi, I came across the same problem (how to calculate MDT) and I foundBack to the Top
the following reference:
Tanigawara Y, Yamaoka K, Nakagawa T, Uno T. New Method for the
Evaluation of in Vitro Dissolution Time and Disintegration Time. (1982)
Vol 30, pp 1088-1090.
In this reference they outline:
MDT = (integral of 0 to infinity)t*(dm/dt)dt" /"" (integral of zero to
They"further state, "The in vitro MDT is calculated in the same way as
the mean in vivo residence time (MRT) of the urinary excretion
rate-time curve by using trapezoidal integration."
In other words, AUMC/AUC for the rate of dissolution versus time
data"is exactly how you can calculate MDT.
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