- On 6 Aug 2004 at 08:30:25, David Dubins (DDubins.aaa.allied-research.com) sent the message
Hi, I came across the same problem (how to calculate MDT) and I found

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the following reference:

"

Tanigawara Y, Yamaoka K, Nakagawa T, Uno T. New Method for the

Evaluation of in Vitro Dissolution Time and Disintegration Time. (1982)

Vol 30, pp 1088-1090.

"

In this reference they outline:

"

MDT = (integral of 0 to infinity)t*(dm/dt)dt" /"" (integral of zero to

infinity)(dm/dt)dt

"

They"further state, "The in vitro MDT is calculated in the same way as

the mean in vivo residence time (MRT) of the urinary excretion

rate-time curve by using trapezoidal integration."

"

In other words, AUMC/AUC for the rate of dissolution versus time

data"is exactly how you can calculate MDT.

-Dave

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