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Now a days i am developing bioanalytical method for Metolazone on
LC-MS. As Metalozone is strongly bound(80%) to RBCs and other blood
cells and about 20% drug available in plasma so i am developing a
method using whole blood.As for plasma there are Liq-liq
extraction,protein ppt,and SPE metod are well known.but for whole blood
bioanalysis anybody is having any reference or experience then please
let me know.
With Regards
Yogesh Patil
Research Scientist
Alembic Ltd.
INDIA
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