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Can anyone provide information about liver weight and microsomal protein
content (in the liver) of rat (Sprague Dawley), dog (beagle), monkey
(cynomolgus) and human ? I=B4m searching for published references.
Thanks in advance,
M'Carmen Gomez
Metabolism & Pharmacokinetics Service
Research & Development Department
IPSEN-PHARMA S.A. Laboratories
Beaufour-Ipsen Group
Ctra. Laurea Miro 395
Sant Feliu de Llobregat, Barcelona, Spain
Telf.: 936858100
e-mail: m-carmen.gomez.-at-.ipsen.com
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Hi,
you may find some information in ;
Houston JB; utility of in vitro drug metabolism data in predicting in
vivo
clearence. Biochem. Pharmacol, 1994, 74, 1469-1479.
best regards
Dirk
Dr. Dirk Scharn
Scientist, DMPK-Lead Discovery
Jerini Pharmaceuticals
Jerini AG
Invalidenstra=DFe 130
10115 Berlin, Germany
Phone: +49-30-9 78 93-369
Fax: +49-30-9 78 93-105
eMail: scharn.aaa.jerini.de
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You can find the information, including the published reference in our
report at the website of our institute:
http://www.rivm.nl/bibliotheek/rapporten/623860010.pdf (page 66)
[6.3MByte/ 100 pages of interesting material - db]
Kind Regards,
Adrienne Sips
AJAM Sips, PhD head department Method and Model development
National Institute of Public Health & the Environment
Center for Substances and Integrated Risk Assessment, U339
P.O. Box 1
3720 Bilthoven
The Netherlands
tel. + 31 30 274 2043
fax. + 31 30 274 4475
e-mail: adrienne.sips.-at-.rivm.nl
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Dear M'Carmen,
Liver weight micros. Prot
(g/kg Body weight) (mg/g liver)
RAT 42-45 45-54
DOG 25.6 43
MAN 20.2 52-77
From
Handbook of essential pharmacokinetics, pharmacodynamics and drug
metabolism for industrial scientists.
Younggil Kwon
Kluwer Academic /Plenum Publishers 2001
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I find this article very useful:
Brian Davies and Tim Morris. Physiological Parameters in Laboratory
Animals and Humans (1993). Pharmaceutical Research, 10(7), 1093-1095.
HANDBOOK OF ESSENTIAL PHARMACOKINETICS, PHARMACODYNAMICS AND DRUG
METABOLISM FOR INDUSTRIAL SCIENTISTS
Younggil Kwon
Kluwer academic/Plenum Publishers, New York, 2001
This book was suggested by Stefano Porzio a few weeks ago in this list.
I hope that helps.
Regards,
Alessandra
Alessandra Milesi-Hall
Department of Pharmacology and Toxicology
University of Arkansas for Medical Sciences
4301 West Markham, slot 611
Little Rock, Arkansas 72205
Phone: (501)686-6551
Fax: (501)686-5521
MilesihalleAlessandr.aaa.uams.edu
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how about microsomes/g liver?
Thanks,
Valeria Chu
Sanofi-Aventis
pre-clinical PK
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Dear Valeria,
Which is the difference between microsomal protein content in the liver
and
and microsomes/g liver? Are we talking about the same?
Regards,
M'Carmen Gomez
Metabolism & Pharmacokinetics Service
Research & Development Department
IPSEN-PHARMA S.A. Laboratories
Beaufour-Ipsen Group
Ctra. Laurea Miro 395
Sant Feliu de Llobregat, Barcelona, Spain
Telf.: 936858100
e-mail: m-carmen.gomez.aaa.ipsen.com
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Inter-individual variability in levels of human microsomal protein and
hepatocellularity per gram of liver.
Z.E.Wilson et. al J. Clin. Pharmacol. 56, 2003, 433-440
Kenan Gu, Ph.D.
Senior Scientist
Tissue Transformation Technologies
PharmPK Discussion List Archive Index page
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