PharmPK Discussion - Monoclonal Antibody SC: absolute bioavailability correlation from mouse to man

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On 20 Jul 2004 at 13:56:57, "David Benziger" (David.Benziger.aaa.cubist.com) sent the message

Does anyone have information or literature references that addresses
the relationship of SC absolute bioavailability of monoclonal or
polyclonal antibodies in the mouse as a predictor of the absolute
bioavailability in man by SC route?
I\0xEDve heard that the SC space in the mouse very different from that of
man. Any general comments or references on this difference?
Lastly, any specific information on the CB6F1 mouse???
Thanks to all.
Dave

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On 26 Jul 2004 at 07:54:06, "David Benziger" (David.Benziger.aaa.cubist.com) sent the message

Does anyone have information or literature references that addresses
the relationship of SC absolute bioavailability of monoclonal or
polyclonal antibodies in the mouse as a predictor of the absolute
bioavailability in man by SC route?
I've heard that the SC space in the mouse very different from that of
man. Any general comments or references on this difference?
Lastly, any specific information on the CB6F1 mouse???
Thanks to all.
Dave

Back to the Top

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