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I am studying oxcarbazepine PK and I found that it's almost completely
absorbed and has bioavailability after oral intake >95%. However they
say it has high first-pass effect metabolism and it is rapidly reduced
It seams that the bioavailability reported is related to the
metabolite, am I right?
Another doubt is that when you say oxcarbazepine has bioavailability of
95%, shouldn't this be related to the unchanged compound?
Thanks for helping me,
Paula Macedo Cerqueira, PhD
Pharmacist- Technical Consultant
National Health Surveillance Agency - ANVISA
Bioequivalence Unity - S\0x201Eo Paulo -SP- Brazil
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Dear Dr. Paul,
I agree with your comments. It's unrealistic to say that Oxcarbazepine
is having 95.0% F. its quite evident that 10MHD the active metabolite
makes a 70% to 80% of the antiepileptic activity, the concentration of
the unchanged Oxcarbazepine is very low although its detectable it also
depend on the metabolism in Liver.
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