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hi all,
I am looking for some info on the evolution and maturation of the P450
enzymes family (and/or all liver enzymes in general) in lab animals
(rat,
dog, monkeys) as a function of age.
Does anybody could direct me to some interesting publication on the
subject.
Thank you for your help,
Pascal
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Hello,
Try neonate, P450 and animal of choice.
neonate rat and P450 gives
Atterberry TT, Burnett WT, Chambers JE. Related Articles, Links
Age-related differences in parathion and chlorpyrifos toxicity in male
rats: target and nontarget esterase sensitivity and cytochrome
P450-mediated metabolism.
as the 7th hit.
I did neonatal development in Holstein bull calves. My office mate
Sakina El Tom did the goats.
Charles Short did perinatal development in swine, JPET, 1970
Also
Annu Rev Pharmacol Toxicol. 1976;16:427-45.
Developmental aspects of the hepatic cytochrome P450 monooxygenase
system.
Neims AH, Warner M, Loughnan PM, Aranda JV.
Good luck
Susan Shoaf
Sr. Pharmacokineticist
Otsuka Maryland Research Inst
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Dear Pascal,
2 recent published papers are
Jill S. Warrington, David J. Greenblatt, and Lisa L. von Moltke
Age-Related Differences in CYP3A Expression and Activity in the Rat
Liver, Intestine, and Kidney
J. Pharmacol. Exp. Ther., May 2004; 309: 720 - 729.
Jill S. Warrington, David J. Greenblatt, and Lisa L. von Moltke
The Effect of Age on P-Glycoprotein Expression and Function in the
Fischer-344 Rat
J. Pharmacol. Exp. Ther., May 2004; 309: 730 - 736.
Best regards
Stefano Porzio
Pharmacokinetic and Tox. Dept.
Inpharzam Ricerche SA - ZAMBON-GROUP
Taverne - Switzerland
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