Hi all,Back to the Top
I have another very naive question. I am in the initial stages of
evaluating efficacy and PK parameters of a novel drug in a murine
xenograft model. I am a biologist not a pharmacologist with no one
really to inform me of the best way to approach the problem. As a
preface to my more specific question, I would be very appreciative if
any one can recommend a good beginner book or course that is available
for someone needing to learning the basics of PK analysis. Also, what
is the best and most widely accepted software for analyzing PK data?
I'm sure there will be differences of opinion on all these questions,
but perhaps I can get a consensus after reading replies.
My specific question or situation is this - I have been evaluating
efficacy by IP delivery and am getting quite good results.I would like
to begin to address the issue of pharmacokinetics, but everything I
have read in the literature suggests that such studies are done when
the drug is administered IV. To me it seems logical that if I am
giving the drug IP for efficacy studies I should also look at PK
parameters after IP delivery. However, I looked through the archives
of the PharmPK site and got some hint that perhaps I need to do the PK
studies with drug administered IV first then compare them to results
from IP delivery in order to make the appropriate calculations. Can
someone explain this to me? Perhaps I just should start over and
repeat the efficacy studies IV? I started doing IP really simply for
convenience (and because I still had not mastered IV injections). I'm
now technically more competent.
UT Southwestern, Dallas Texas
[Have you looked at http://www.boomer.org/c/p4/ - also look at
http://www.boomer.org/pkin/soft.html for a list of PK software or
http://www.boomer.org/pkin/book.html for PK books - db]
Hi:Back to the Top
It is necessary to perform IV studies to obtain the PK parameters
first, followed with IP studies to show how much is bioavailable. Not
all PK parameters can be obtained from IP studies.
For practical purpose, you don't normally stick the patient IP, so you
should do an IV efficacy study anyway.
Vuong Trieu PhD
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