I like to get the kind of information you requested (e.g., OxyContin)Back to the Top
by using a PubMed Boolean search. The appropriate link follows:
For example, if you wish information on OxyContin (SR oxycodone),
youmight search "oxycodone and pharmacokinetic and prolonged," or
"oxycodone and pharmacokinetic and absorption," or "oxycodone and
absorption and human," etc. If you get too many hits, try adding "and
review" to get a review article.
One of the interesting characteristics of good sustained-release
products is that they are "flip-flop" systems, i.e., absorption is
rate-limiting, and the plasma concentration-time curve is proportional
to rate of absorption. If you look at the OxyContin plasma
concentration-time profiles, you will note rapid absorption during
early time-points. This may contribute to the addiction liability of
patients taking this SR dosage form properly for legitimate purposes.
You can contrast this with the oral plasma concentration-time profile
of oral SR nifedipine (Pfizer) which has an excellent release profile.
Happy literature mining. Harold.
Harold Boxenbaum, Ph.D.
14621 Settlers Landing Way
North Potomac, MD 20878-4305
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)