PharmPK Discussion - pKa of floxuridine

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On 27 Apr 2004 at 10:49:21, "Sherwin Xie [VH]" (sxie.-at-.vanhosp.bc.ca) sent the message

Hi all,
I am working on floxuridine (FUdR) and could not find the PKa value (at
any temperature). Have spent days on literature searching yet found
nothing. If you happen to have this information, or you know a good
source of PKa information for chemotherapeutic compounds, please let me
know.
Thank you.
(Sorry for the "not-exactly-PharmPK-question")
Sherwin
Vancouver, Canada
[I assume it is for an assay problem or understanding
absorption/distribution of the drug ;-) - db]

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On 27 Apr 2004 at 19:48:18, Huadong Sun (hd.sun.aaa.utoronto.ca) sent the message

pKa = 7.6
You can search the online service of sigma company. www.sigma.com
normally, you will find something useful.
Also, it gave the following reference you can check with:
Dawson, R. M. C., et al., Data for Biochemical
Research, 3rd ed., p. 267., Oxford University
Press, New York, (1986)
--
314 Room, 19 Russell Street
Faculty of Pharmacy
University of Toronto
Toronto, Ontario M5S2S2
(Tel) 416-978-6996
(Fax)416-978-8511

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On 28 Apr 2004 at 08:12:41, "Ving Lee" (vlee.at.anacor.com) sent the message

Sherwin,
Floxuridine is 2'-deoxy-5-fluorouridine.  The acidic moiety is the
5-fluorouracil moiety.  Thus, one should be able to approximate the pKa
from other analogs in the literature like i) 5-FU THF which is sold by
Taiho-Otsuka or 2) 5-fluorouridine.
Hope this helps,
Ving J. Lee
Anacor Pharmaceuticals
Palo Alto, California 94303

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