Hi All,Back to the Top
We have done few monkey PK studies,where the compounds were given by
oral and intravenous route at matching doses.
The elimination half life for one of the compound is different for per
os (3.5 hr) route as compared to i.v. route (1.6 hr). In oral route we
get good measurable concentrations at 24 hr, while no drug is found at
24 hr by i.v. route.
What could be the reasons for difference in t1/2 by oral and i.v.
route. I would appreciate some thoughts and comments.
[Slow absorption -db]
May be the absorption is not over during the concentration-time course,Back to the Top
and after po dosing, you measure in fact the absorption instead of the
elimination process. Is you oral form a slow release formulation?
Hope this help
Is it possible that flip-flop kinetics is going onBack to the Top
Hi, Sandeep:Back to the Top
This will depend on your molecule and chiral center. There are
commercially available chiral HPLC columns as well as a variety of
chiral mobile phase additives available. GC might also be a choice.
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