Dear PharmPK,Back to the Top
Does anyone know of where you can order a suitably pure reference
standard of N-acetylisoniazid for a LC MS assay?
Thanks very much.
Division of Pharmacology
K45-68 Old Main Building
Groote Schuur Hospital
Tel. +27 (0)21 406 6498
Fax. +27 (0)21 448 1989
I did my thesis in the late 1960s on isoniazid, and synthesized acetylBack to the Top
isoniazid. It's a very easy synthesis, as I recall, maybe just
reacting isoniazid with acetyic anhydride (but not sure). The
reference is Fox HH Gibas JT. J Org Chem, 18:1375(1953). Good luck.
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