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Hello all,
This might be a silly question but I wonder if anyone can tell me
whether it is
possible to use a scale-up factor to apply parameters (Jmax or Km) of
saturation mechanism by transporter-mediated efflux (such as Pgp) in
mouse or
rat to human intestine.
if it's possible, is there any commone equation or factor that is used?
Any comment would be greatly appreciated.
Thank you.
HJ.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)