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Dear all,
I have a question for you. Which is the most suitable way to measure
solubility of a compound when you have just few mg of it?
Thanks
Federica
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Dear Frederica,
look under: Li et al., J Pharm Sci. Vol. 82, No. 2 (1998): "Evaluation
of
in vitro precipitaion methods".
If you want to search for further literature, look for the papers
published
by Samuel H. Yalkowsky. He did great work in the field of early
formulation
development.
best regards,
Philip
Philip Lienau
Schering AG
Research Pharmacokinetics
Tel.: +49 - 30 - 468 - 18507
Fax: +49 - 30 - 468 - 12238
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Solubility measurement is probably one of the most improperly performed
experiments in the industry. In the rush to develop high throughput
methods to measure solubility, many companies have come up with methods
that are "quick and dirty". Speed obtained with these methods is often
offset by data that are not solubility at all, but at best a measure of
dissolution within a certain (short) period of time. This may be
suitable for some initial screening, but if you really want to know the
thermodynamic solubility of a compound in a particular medium, it takes
more time and care.
The new book, "Absorption and Drug Development" by Alex Avdeef (ISBN
0-471-42365-3, Wiley-Interscience, 2003), provides a nice discussion of
various solubility measurements.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (AMEX: SLP)
1220 W. Avenue J
Lancaster, CA 93534-2902
U.S.A.
http://www.simulations-plus.com
Phone: (661) 723-7723
FAX: (661) 723-5524
E-mail: walt.-a-.simulations-plus.com
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