PharmPK Discussion - Solubilization of water insoluble drug

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On 19 May 2004 at 19:39:08, tushar nahata (tushar_nahata.aaa.yahoo.com) sent the message

Dear friends,
                     I am also working on solubilization of one water
insoluble drug 0.01 mg/ml (Nitroimidazole derivative) can you suggest any
method by which i can enhance solubility of that drug.
Tushar Nahata

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On 20 May 2004 at 20:36:46, deepak bhatia (bhatiadipak.-at-.yahoo.com) sent the message
```
Try cyclodextrin to solubilize your derivative
Deepak
```
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On 20 May 2004 at 20:57:21, "Venkatesh. P" (venknish2002.aaa.yahoo.co.in) sent the message

Dear Tushar,
First try with an Organic cocktail formulation including DMSO, PEG,
Cremophor up to 30%.
If still you are not able to get good formulation it is better to use the
solution of 5% cyclodextrin.
it is better to warm the solution to get clear solution of cyclodextrin. if
the drug is not soluble in 5% B-cyclodextrin, it is better to opt water
soluble derivative of Hydroxy propyl B cyclodextrin or sulfa butyl ethrer
cyclodextrin. if still drug is not soluble it is prefered to use cosolvent
along with Hydroxy propyl B cyclodextrin.
Hope this will help for you
Venkatesh.P
Senior Pharmacologist,
Dept of Drug Metabolism and Pharmacokinetics,
Discovery Research, Dr.Reddy's Labs.
Hyderabad, India-500050.
Phone no:91-9849692908

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On 21 May 2004 at 19:42:56, =?iso-8859-1?Q?Fr=E9d=E9ric?= DOC (fredericdoc.-at-.netcourrier.com) sent the message

Hi,
if you try to solubilize with cyclodextrin, do not forget to evaluate the
complexation between the active drug and the cyclodextrin. This will
prevent from any cyclodextrin-related modified release.
Hope this helps,
Frederic Doc
ex-Pfizer
CEO and co-founder, ACRITER Consulting
--
Hello Venkatesh,
could you explain your formulation approach ? I would be very glad if you
could detail your methodology.
Thanks in advance,
Frederic Doc
ex-Pfizer
CEO and co-founder, ACRITER Consulting
--
Hello Tushar,
which kind of studies do you need a formulation for ?
which kind of route of administration would you like a formulation for ?
With those answers it will be possible to give a precise methodology to try
and solve your solubility issue.
Best regards,
Frederic DOC
ex-Pfizer
CEO and co-founder, ACRITER Consulting

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On 22 May 2004 at 19:42:34, "Sandeep Kachhwaha" (skachhwaha.-at-.astron-research.com) sent the message

Dear Frederic,
Can you suggest any reference to evaluate the complexation between the
active drug and the cyclodextrin?
Thanks in advance.
Regards,
Sandeep
ASTRON RESEARCH LTD.,
Premier House,  Bodakdev,  Gandhinagar Sarkhej Highway,  Ahmedadad - 380
054 , INDIA
Tel   :  + 91 79 26853518    Fax  :  + 91 79 26840224

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On 24 May 2004 at 10:24:40, (fredericdoc.-at-.netcourrier.com) sent the message

Hello,
I do not have the exact reference but you can find articles from Valentino
J. Stella who worked on this topic.
Hope this helps
Frederic

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