PharmPK Discussion - Solvent for dissolving some extracts

PharmPK Discussion List Archive Index page

On 23 Mar 2004 at 13:03:30, "Poonam shokeen" (psjrf.-a-.rediffmail.com) sent the message

Dear all
I have to administer some plant extracts to mice orally.These extracts
are soluble upto some extent in DMF(Dimethylformamide),80% ethanol and
to a lesser extent in DMSO(Though a clear solution is not obtained in
any of the above case). These extracts are insoluble in almost all the
other solvents which I tried. All the extract are in paste form and
very sticky.Can any oil be used to dissolve them.Can anyone guide me
whether extracts dissolved in DMF/DMSO/80% ethanol (In suspension form
as I am getting) can be given to mice and upto what percent these are
permissible for giving to mice. Is there any reference for any other
solvent which can be  given orally  to mice and upto what percent.
Any answer to these questions would be of great help in my work. And I
would be very obliged.
Thanks in advance
my alternate emailid is poonam_pcp.at.hotmail.com
Poonam Shokeen
Research Scholar,
Dr.B.R.Ambedkar Center
for BIomedical Research,
University of Delhi,
Delhi 110007,
Phone-7666272/7667151 Extn-248
Fax-7666248

Back to the Top

On 28 Mar 2004 at 19:17:08, "conny keck" (conny-keck.aaa.web.de) sent the message


Dear Poonam,
I think you could solve your formulation problem by transferring your
insoluble matrial to drug nanocrystals by high pressure homogenisation.
The obtained nanocrystals possess a high surface area and show an
increased
saturation solubility, hence they dissolve extremely fast in the gut.
For
more informations go to the hompage of Prof. R.H. Muller
www.muller-berlin.com.
Drug nanocrystals are a universal formulation principle for poorly
soluble
drugs, they can be administered via the dermal, oral, parenteral,
pulmuary
and ocular route.
Best regards
conny

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Solvent for dissolving some extracts" as the subject

PharmPK Discussion List Archive Index page