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I have to administer some plant extracts to mice orally.These extracts
are soluble upto some extent in DMF(Dimethylformamide),80% ethanol and
to a lesser extent in DMSO(Though a clear solution is not obtained in
any of the above case). These extracts are insoluble in almost all the
other solvents which I tried. All the extract are in paste form and
very sticky.Can any oil be used to dissolve them.Can anyone guide me
whether extracts dissolved in DMF/DMSO/80% ethanol (In suspension form
as I am getting) can be given to mice and upto what percent these are
permissible for giving to mice. Is there any reference for any other
solvent which can be given orally to mice and upto what percent.
Any answer to these questions would be of great help in my work. And I
would be very obliged.
Thanks in advance
my alternate emailid is poonam_pcp.at.hotmail.com
for BIomedical Research,
University of Delhi,
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I think you could solve your formulation problem by transferring your
insoluble matrial to drug nanocrystals by high pressure homogenisation.
The obtained nanocrystals possess a high surface area and show an
saturation solubility, hence they dissolve extremely fast in the gut.
more informations go to the hompage of Prof. R.H. Muller
Drug nanocrystals are a universal formulation principle for poorly
drugs, they can be administered via the dermal, oral, parenteral,
and ocular route.
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