PharmPK Discussion - Thiol glucuronidation

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On 21 Jun 2004 at 16:28:10, "Bhamidipati Ravikanth" (bravikanth.at.email.com) sent the message

  Dear All,
Can anybody give me examples of the compounds undergoing thiolic
glucuronidation
Regards,
Ravi Kanth Bhamidipati
Senior Pharmacologist
Dept.of Drug Metabolism and Pharmacokinetics
Discovery Research Division
Dr.Reddy's Laboratories Ltd.
Bollaram Road , Miyapur
Hyderabad - 500 050
Andhra Pradesh
India

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On 21 Jun 2004 at 13:41:50, "Pusalkar, Sandeepraj" (Sandeepraj.Pusalkar.at.mpi.com) sent the message

Hi Ravi,
Look up the following references:
1. Ethell, Brian T.; Riedel, Jens; Englert, Heinrich; Jantz, Herbert;
Oekonomopulos, Raymond; Burchell, Brian.  Glucuronidation of HMR1098 in
human microsomes: Evidence for the involvement of UGT1A1 in the
formation of S-glucuronides.    Drug Metabolism and Disposition  (2003),
31(8),  1027-1034.
2. Martin, Iain J.; Lewis, Richard J.; Bonnert, Roger V.; Cage, Peter;
Moody, Graeme C. NMR identification of an S-linked glucuronide of a
triazole thione formed in vitro. Drug Metabolism and Disposition
(2003),  31(6),  694-696.
Sandeepraj Pusalkar
Scientist
Department of Biotransformation, DMPK
Millennium Pharmaceuticals, Inc.
45 Sidney Street,
Cambridge, MA 02139

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On 22 Jun 2004 at 12:18:53, Kasiram Katneni (kasiram.katneni.-at-.vcp.monash.edu.au) sent the message
```
Hi Ravi,
Etodolac, Methimazole, Disulfiram are few examples.
Kasiram.
```
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