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The following message was posted to: PharmPK
Recently our anesthetic drug discovery work led to the formulation
stage.
Is there any guide on standard vehicles for oral formulations,
from which we can easily follow to choose for our in vivo evaluation
of these prodrugs? Thank you and I appreciate it.
....from a list member
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The following message was posted to: PharmPK
Dear David,
when dosing a drug orally, you have the advantage to use
microcrystalline
suspensions. Oral formulations have the advantage, that they don't need
to
be a solution and by applying a suspension, you'll learn a lot about the
solubility behaviour of the drug and its impact on the in vivo situation
(absorption).
If you prefer to use an oral solution (there might be also good reasons
to
do so), you can use the following reference which was published by the
Pfizer formulation group in Ann Harbour for iv vehicles: Lee et al.,
Int.
J. Pharm. 253, (2003) 111-119 An intravenous formulation decision tree
for
........
best regards,
Philip
Philip Lienau
Schering AG
Research Pharmacokinetics
Tel.: +49 - 30 - 468 - 18507
Fax: +49 - 30 - 468 - 12238
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The following message was posted to: PharmPK
There is no standard it depends on the dosage form you have designed.
For instance If is a tablet/capsule then you have to use simulated
gastric or intestinal juice. If it is a suspension you may not require
the test. etc dosage forms
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)