What is the appropriate PK/PD monitoring for Vancomycin, AUC orBack to the Top
time-above-MIC. I would believe the later would be more important since
Vanco has a short post-antibiotic effect (1,5hrs) and increasing the
concentration above the MIC does not markedlly increase the
Ricardo,Back to the Top
Vancomycin is time-above-MIC pharmacodynamics profile.
Ving J. Lee
Technical Consultant-VP Discovery
Anacor Pharmaceuticals, Inc.
Palo Alto, California 94303
Back to the Top
Vancomycin exhibits a pharmacodynamic profile which includes
time-dependent bactericidal activity with concentrations normally
achieved in-vivo, and moderate persistent effects. The pharmacodynamic
surrogate for efficacy is therefore AUC/MIC.
Craig WA. PK/PD parameters: rationale for antibacterial dosing
of mice an men. Clin Infect Dis 1998;26:1-12.
Efficacy in patients as well as potential for development of resistance
has also been linked to vancomycin AUC/MIC ratios.
Hyatt J, et al. Clin Pharmacokinet 1995;28:143-160.
Thomas JK, et al. Antimicrob Agents Chemother 1998;42:521-527.
Paul Beringer, Pharm.D.
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