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Dear members,
Pellets were produced by extrusion-spheronization method after mixing
drug with different excipients. The in vitro dissolution profiles are
based on the data provided as follows. What puzzles me is why there is
a lower point at 20 min respectively for formulation 3&4 ? What affects
the dissolution ? Is it because of the characters of different
excipients
Thanks for your comments!
formulations:
1.pvpp 20.5g, mcc 27g, % dissolution at 10min,20min,30min and 40min is
52.14,68.26,74.52
81.47 respectively
2.l-hpc 27g, mcc20.5g, % dissolution at 10min,20min,30min and 40min is
50.31,60.11,68.36,73.15 respectively
3.l-hpc20.5g, mcc 27g, % dissolution at 10min,20min,30min and 40min is
81.5,71.63,81.25,85.11 respectively
4.mcc 47.5g, % dissolution at 10min,20min,30min and 40min is
66.55,60.24,79.47,85.05 respectively
HPC is forming gel as soon as it comes in contact with water. So inBack to the Top
first 10 minutes, drug release is due to burst release but after that,
HPC is not releasing the drug as it is in the process of gel formation.
Thanks,
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I feel that without more details ( which compound is studied, which
dissolution test is used, how is sampling performed ?) it is quite
impossible to give an explanation for this unusual phenomenon.
Kind regards
Prof. Dr. R. KINGET
Dorpsstraat 139
B-3060 BERTEM
Belgium
Tel/Fax 32- (0)16 49 01 49
http://www.farm.kuleuven.ac.be/pharbio/vraagbox.htm
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)