- On 5 Mar 2004 at 14:14:22, "Tata, Prasad N" (Prasad.Tata.at.TycoHealthcare.com) sent the message
Dear All:

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In the non compartmental analysis using WinNonlin I am trying to

generate a summary table listing the terminal phase characteristics,

slope, intercept, Kel (slope is Kel), T1/2. I am not able to capture

slope and intercept information into this summary table. Can someone

help me on this issue?

Prasad Tata

St. Louis, MO 63134 - On 5 Mar 2004 at 17:27:30, Ayyappa Chaturvedula (chaturvedu_a.at.ACADMN.MERCER.EDU) sent the message

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Hi,

In WinNonlin (4.1), there is an option in the parameters screen (where

we can

check the units)to select which parameters should be calculated and

which

should not. I assume the parameters you are specifying may be checked

for

'no'. Please check that before asking it to 'model'.

Thanks,

Ayyappa Chaturvedula

Graduate Student

Mercer University

Thanks.

Ayyappa - On 5 Mar 2004 at 18:11:46, ArmenP.aaa.aol.com sent the message
Prasad: The WinNonlin .pwo output file reports Kel as Lambda_z. To

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output this variable into a table by using the Table Wizard is the same

for Camx, AUC,etc. (you just select it as one of the variablesto place

in the table you are creating). I am not sure why you want to report

"intercept." Of course, there is the y- and the x-intercepts. First

of all, either one of these has to be calculated. When using the

WinNonlin Model 201 (IV input bolus), the y-intercept is calculated and

reported in the .pto output file as the concentration at time 0 for the

purpose of the trapezoidal calculation of AUC. This may not be the

y-intercept of the slope, but an extrapolation of the first phase.

The intercepts based on the regression for the slope have to be

calculated. The .pwo file also acts as spreadsheet, and the intercepts

can be calculated for each subject's data by using entering the

formulas and data.As I said above, the reason for presentation of

intercepts of the slope for PKis one I don't understand. If the

reason is to preent the caracterisctics of the regression, Rsq in the

.pwo and .pto output files may be more meaningful.

Hope this helps.

Armen Melikian

Drug Development Resources, LLC

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