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The following message was posted to: PharmPK
I am trying to develop a population PK model with WinNonmix.
Unfortunately I don't have much experience with it and don't know how
to handle many of the error messages. Does anyone know if there is a
list of those messages and more important how to handle them? The
user's guide is not much help as it doesn't provide any information how
to solve the problems.
At the moment I have problems with the following error messages using
the conditional first order method:
10510 FAILURE TO ESTIMATE MODEL PARAMETERS WITH PENALIZED NONLINEAR
LEAST SQUARES. Program Terminated with Fatal Error.
-I have tried to change model specifications and initial estimates,
with no result.
10804 FAILURE AT LIKELIHOOD MAXIMIZATION. Program Terminated with
-Sometimes it helps to change initials for etas, but not always.
Does anyone know how to proceed after these messages? Any help would be
highly appreciated! Thank you!
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