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The following message was posted to: PharmPK
Dear Colleagues,
Could you please provide me information with regard to the change of
CYP2D6 metabolic capacity for drugs with age or body weight? Thanks a
lot
Konstantinos Avgoustakis, PhD
Department of Pharmacy,
University of Patras,
Rio 26500, Greece
Tel:++2610-969330
Fax: ++2610-996302
Email: avgoust.aaa.upatras.gr
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The following message was posted to: PharmPK
Dear Konstantinos,
Did you try to search on keywords in the regular literature search
engines like pubmed or google scholar? A simple search may provide
you with dozens of answers.
Tanaka E. - In vivo age-related changes in hepatic drug-oxidizing
capacity in humans - Journal of Clinical Pharmacy & Therapeutics,
Volume 23, Number 4, August 1998, pp. 247-255(09)
Jean-Marc TRELUYER, Evelyne JACQZ-AIGRAIN, Fernando ALVAREZ and
Thierry CRESTEIL, Expression of CYP2D6 in developing human liver,
European Journal of Biochemistry Volume 202 Issue 2 Page 583 -
December 1991
And there is a whole lot more to be found...
Cheers,
--
Rob ter Heine, MSc, PharmD
Department of Pharmacology, Slotervaart Hospital
Amsterdam, The Netherlands
E: aprth.-a-.slz.nl
T: 020-5124737
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