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The following message was posted to: PharmPK
Some researcher in the early investigation on PK-PD relationschip of
irinotecn introduced the use of of biliary index as a surrogate
biliary excretion of the SN38 active metabolite of irinotecn that
with the risk of diarrhea.
they defines the biliary index as following:
BI= AUC SN38/AUC SN38G*AUC Irinotecan.
Where SN38 is the active metabolite of irinotecn, SN38G is it
and Irinotecn the parent drug.
Can somebody help me to clarify the meaning of such AUC ratio ?
moreover such parameters can be use properly in PK-PD correlation
with heamtologica toxicity and response?
Many thank in advance for the help
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