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The following message was posted to: PharmPK
Can any one suggest biorelevent media simulating fed condition in
stomach.
Thanks & Regards
Manoj Kumar Vishwakarma
Group- Leader
Biopharmaceutics
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Hi Manoj
Jennifer B Dressman has couple of papers on this aspect. All you could
do is a search in PubMed and you will find a handful.
Best of Luck
Manish Issar
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Hi
Below are some of the references. You can contact Prof. Dressman at
Dept of Pharmaceutical Technology, University of Frankfurt, Frankfurt
Biocentre, Germany website. They use some novel medias for these type
of studies.
regards,
Jagdish
1: Klein S, Butler J, Hempenstall JM, Reppas C, Dressman JB.
Media to simulate the postprandial stomach I. Matching the
physicochemical
characteristics of standard breakfasts.
J Pharm Pharmacol. 2004 May;56(5):605-10.
PMID: 15142337 [PubMed - indexed for MEDLINE]
2: Vertzoni M, Fotaki N, Kostewicz E, Stippler E, Leuner C, Nicolaides
E,
Dressman J, Reppas C.
Dissolution media simulating the intralumenal composition of the small
intestine: physiological issues and practical aspects.
J Pharm Pharmacol. 2004 Apr;56(4):453-62.
PMID: 15099440 [PubMed - indexed for MEDLINE]
3: Willmann S, Schmitt W, Keldenich J, Dressman JB.
A physiologic model for simulating gastrointestinal flow and drug
absorption in
rats.
Pharm Res. 2003 Nov;20(11):1766-71.
PMID: 14661920 [PubMed - indexed for MEDLINE]
4: Kostewicz ES, Brauns U, Becker R, Dressman JB.
Forecasting the oral absorption behavior of poorly soluble weak bases
using
solubility and dissolution studies in biorelevant media.
Pharm Res. 2002 Mar;19(3):345-9. No abstract available.
PMID: 11934243 [PubMed - indexed for MEDLINE]
5: Nicolaides E, Symillides M, Dressman JB, Reppas C.
Biorelevant dissolution testing to predict the plasma profile of
lipophilic
drugs after oral administration.
Pharm Res. 2001 Mar;18(3):380-8.
PMID: 11442280 [PubMed - indexed for MEDLINE]
6: Nicolaides E, Galia E, Efthymiopoulos C, Dressman JB, Reppas C.
Forecasting the in vivo performance of four low solubility drugs from
their in
vitro dissolution data.
Pharm Res. 1999 Dec;16(12):1876-82.
PMID: 10644077 [PubMed - indexed for MEDLINE]
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