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I have a question about how to compare the two plasma-concentration
curves from PK study on mice.
We have two groups, with seven time points on each curve. The data
from three mice were averaged for each time point.
As you know, each mice will be euthanized for each data point, thus
it is not the repeated measurement on one subject.
So how to compare the difference of the two curves? Can I run some
statistical test and conclude there is significant difference between
the two curves?
Or I can only get some parameters such as AUC, Clearance? You know,
even I got those parameters, I can not do any statistical analysis.
Thanks a lot.
Division of Pharmaceutics
the Ohio State University
Columbus, Ohio 43210
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The following message was posted to: PharmPK
Try Wang J. Optimal design for linear interpolation of curves.Stat
Med. 2001 Aug 30;20(16):2467-77.
This paper proposes optimal designs that minimize the mean squared
error of linear interpolation. Optimal designs for three situations
are considered. The first... The third situation is destructive
sampling where estimating the average curve is the main purpose. In
the first situation, the design results in the best linear
interpolation when the variance is constant. For the destructive
sampling design, an algorithm based on approximations is proposed.
Mayo and Buchsbaum A robust summarize-regress procedure for tissue-
J Biopharm Stat. 2000 May;10(2):251-64
Bialer and Ruberg Randomization tests for assessing the equality of
area under curves for studies using destructive sampling J Appl
Toxicol. 1996 Sep-Oct;16(5):391-5.
Mager and Goller Resampling methods in sparse sampling situations in
preclinical pharmacokinetic studies. J Pharm Sci. 1998 Mar;87(3):372-8.
Vandenhende F, Comblain M, Delsemme MH, Dewe W, Hoffman WP, Boulanger
B. Construction of an optimal destructive sampling design for
noncompartmental AUC estimation J Pharmacokinet Biopharm. 1999 Apr;27
Nedelman JR, Gibiansky E. The variance of a better AUC estimator for
sparse, destructive sampling in toxicokinetics. J Pharm Sci. 1996 Aug;
I used "destructive sampling" pharmacokinetic as search words in PubMed.
Susan Shoaf, Ph.D.
Clinical Pharmacology, Clinical Development
Otsuka Maryland Research Inst.
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