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Does anyone know the possible effect of the composition of an
intravenous formulation on the calculated value of the volume of
distribution at steady state?
Anyone with an idea?
Thanks in advance,
Koen Wuyts
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Dear Koen,
An example is the effect of Cremophor EL on paclitaxel protein
binding. The addition of this formulant leads to entrapment of
paclitaxel in Cremophor micelles leading to a lower unbound fraction
(8% unbound without Cremophor and 2% unbound with 1% Cremophor).
Since Vdss is highly dependent on the unbound fraction, this
formulation would lead to altered Vdss.
Andrea Edginton
Ref: van den Bongard et al. 2004. Development and validation of a
method to determine the unbound paclitaxel fraction in human plasma.
Analytical Bioichemistry. 324: 11-15.
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