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I'm looking for infromation on SC BA from arm, thigh and abdomen.
Also effects of drug concentration on BA (my drug a monoclonal at 20
or 40 mg/mL in PBS) assuming 1 mL injection of each
Any thoughts of administering the 40 mg as 2 X 1 mL SC doses of 20?
Get additive profile?
Effects of concentration on absorption profile?
Thanks - Dave
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The following message was posted to: PharmPK
I am also working on the influence of different injection sites on
bioavailability, however my work is in rat and sheep and I use protein
drugs in my studies. I read a review article which may be of some use to
you as it reviews the influence of area of the injection site, volume of
formulation, concentration of solution and molecular size of the
The review article is: Biopharmaceutical considerations in subcutaneous
and intramuscular drug administration, Berton E. Ballard, Journal of
Pharmaceutical Sciences, March 1968, Volume 57, Number 3.
To my knowledge I could understand from my studies that the injection
site probably influences the rate of absorption though the
bioavailability may be same. In my studies this could be due to the
variability in movement of the muscles surrounding the injection site or
area available for the distribution of the injected solution. Movement
and massaging is known to influence the absorption of drugs from
Hope this helps,
Victorian College of Pharmacy
381 Royal Parade
Work: +61 03 9903 9525
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