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Dear All,
I need to find elimination constant or (Clearance and volume) of
methylprednisolone, prednisone, and prednisolone in humans, if
possible at high dosages (2 mg/kg). Could somebody give me any
published references?
Thanks in advance,
Celine
--
Celine Dartois
EA 3738
Universite de Medecine de Lyon sud BP 12
69 921 Oullins cedex
FRANCE
tel : +33 (0)4 26 23 59 64
fax: +33 (0)4 26 23 59 76
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Dear Celine,
Please see the following reference, which is readily available online:
.. Mager DE, Jusko WJ. Quantitative structure-pharmacokinetic/
pharmacodynamic relationships of corticosteroids in man. J Pharm Sci.
2002 Nov;91(11):2441-51.
For in-depth information please consider the following two book
chapters:
.. Jusko WJ, Ludwig EA. Corticosteroids. In Applied Pharmacokinetics,
Evans WE, Schentag JJ, Jusko WJ (eds). Applied Therapeutics Inc:
Vancouver, 1992; 1-34.
.. Mollmann H, Balbach S, Hochhaus G, Barth J, Derendorf H.
Pharmacokinetic-pharmacodynamic correlations of corticosteroids. In
Handbook of Pharmacokinetic/Pharmacodynamic Correlation, Derendorf H,
Hochhaus G (eds). CRC Press Inc: Boca Raton, 1995; 323-361.
Best wishes,
Mahesh
--
Mahesh N. Samtani, Ph.D.
Scientist, Advanced PK-PD Modeling & Simulation
Clinical Pharmacology and Experimental Medicine
Johnson & Johnson Pharmaceutical R&D
PRD 2723, Raritan, NJ 08869
PH # (908) 704-5367
Email: msamtani.aaa.prdus.jnj.com
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