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The following message was posted to: PharmPK
I have a question about pharmacokinetics of enoxaprin. The Cmax is
about
3.5 to 4.5 hours. But before it hits Cmax, it anti-Xa activity would go
to
0.6 iu/ml then dip back to 0.4.iu for an hour and then go back to 0.7
to 0.8
iu/ml again until it reaches Cmax at about 4 to 6 hours sometimes. Can
anyone explain why the dip?
Thanks.
Hoichi cheung
Rph
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The following message was posted to: PharmPK
Hi Hoichi
"But before it hits Cmax, it anti-Xa activity would go
to
0.6 iu/ml then dip back to 0.4.iu for an hour and then go back to 0.7
to 0.8
iu/ml again until it reaches Cmax at about 4 to 6 hours sometimes. Can
anyone explain why the dip?"
Our group has been involved in analysis of several enoxaparin data sets
and I do not recall seeing second peaks. Indeed the concentrations
just go up and then down with very little odd behaviour. Can you tell
us more about how you are administering enoxaparin. [NB This could
just be assay error - it would be useful to check to see if this
happens consistently for all patients.]
Steve
Stephen Duffull
School of Pharmacy, University of Queensland, Brisbane 4072, Australia
Tel +61 7 3365 8808, Fax +61 7 3365 1688
University Provider Number: 00025B
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The following message was posted to: PharmPK
How many patients presented this kinetics? What were the sampling times?
Dr Brigitte Tranchand
EA3738 CTO
Fac Medecine Lyon-Sud
BP12
69921 OULLINS Cedex
France
Tel 33 4 78 86 31 53
Fax 33 4 78 86 31 49
e-mail : Brigitte.Tranchand.-a-.adm.univ-lyon1.fr
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The following message was posted to: PharmPK
we have never seen this type of second peak for
enoxaparin in animals or humans. but we did see a flat
curve between 2 and 4 hours in primates. considering
the low anti-xa activity mentioned in the email, most
likely, it is a measurement error.
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