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The following message was posted to: PharmPK
Dear all, What would be the best PK use of simultaneous samples obtained
from portal vein and peripheral vein assuming we have a portal blood
flow rate value. We are administering the drug by the oral route. How
can one evaluate from a PK standpoint the first-pass effect? References
are appreciated.
JP Moreau
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The following message was posted to: PharmPK
Dear Jean-Pierre:
with this animal model you get the fraction of dose absorbed or
respectively,
the fraction of dose lost within gut lumen and gut wall. In addition
you get an
estimate of hepatic extration ratio.
K. Tabata et al Pharmaceutical Research 12: 880-883, 1995.
D. Hoffman et al Pharmaceutical Research 12: 889-894, 1995.
Freundliche Gruesse / Best Regards
Elke Stahl
Bayer HealthCare AG
PH-PD-P-PPK-FK
Elberfeld
Tel.: +49 202 36 4625
Fax: +49 202 36 4224
e-mail: elke.stahl.aaa.bayerhealthcare.com
Internet : http://www.bayerhealthcare.com
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The following message was posted to: PharmPK
Dear Jean Pierre,
In addition to elke remarks, I will add that if the drug you are
administering per os is lipidic you have to check the passage via the
lymphatics by cannulating the mesenteric canal. (see publications by
W.N.A Charman especially in /drug delivery reviews)
Frederic lagarce
--
Frederic Lagarce, Pharm-D, Ph-D
Inserm U 646, Ingenierie de la vectorisation particulaire
10 rue A Boquel, 49100 Angers
tel 33 (2) 41 73 58 55
fax 33 (2) 41 73 58 53
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