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The following message was posted to: PharmPK
Dear All,
Does anyone have access to the physicochemical
properties of Glycyl-Sarcosine (Gly-sar), the
prototype substrate for the oligopeptide transporter
hPept1. Specifically, pKa and log P.
I am trying to correlate theoretical
(software-predicted) ClogP of Gly-sar at pH 6.0 and pH
7.4 to the experimentally observed values in our
study.
I will appreciate if someone can share the values or
relevant references.
Thanks a lot !
Santosh Dixit
Doctoral Candidate
College of Pharmacy
Department of Pharmaceutical Sciences (Biopharmaceutics)
University of Cincinnati Medical center
3223, Eden Avenue
Cincinnati , OH 45267-004
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