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I agree with Hans Proost's comments about bioavailability from SC vs
the lack of relevance of arterial bioavailability. Following on from
does anyone have data they can share from nasal sprays?
I have found the onset of action of a CNS active drug like fentanyl
rapid by the nasal route, suggesting that some of it at least goes
into the brain. If so I would like to know if anyone has data on the
relative proportions that go into the brain when the IV and the nasal
Guildford Clinical Pharmacology Ltd.
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