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I have a query:
We conducted a three-way crossover bio-equivalence study with 18
volunteers, in that two volunteers didn't turn up for period2, so we
dosed them separately for period2 and period3, there is a sufficient
washout between each periods, compliance to protocol.
1. Is it ok to dose these volunteers separately?
2. For finding the group effect by period, can we use the
By considering the group variable as (Group1=subjects dosed on day1
(Subjects 1-6,8-11 and 13-18), group2= subjects dosed on day2
(Subjects 7and 12)).
I will be grateful if someone could suggest me.
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