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Hello.
We are trying to find the interaction potentials of a herbal juice
with drugs. We are planning to administer the juice and certain drugs
known to be substrates of the CYP450 isozymes of interest. After
going several literature, I noticed there are two ways of getting
this done in vivo
1. Administer both extract and find out the ratio of the enzyme
substrate and the specific metabolites which are obtained as a result
of the enzymatic action before and after administartion of the extract
2. Evaluate the Pharmacokinetics of the ezyme substrate without and
with adminiastration of the juice, and then compare using appropriate
statistical software.
Our problem is that we are finding the metabolites quite expensive to
buy and since this is still a preliminary work, we are thinking of
using the second option.
Please, what do you think.
T Fakeye
University of Ibadan
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