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Hi,
2days back i have sent the mail to the group regarding ivivc and ivivr.
I have doubt that, how to proceed with ivivc.
IVIVC is compare with same type of formulation or for formulation
having less absorbance and other than oral like nasal, external etc.
kindly clarify the doubt.
thanks in advance.
devisha.
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The following message was posted to: PharmPK
Devisha
Perhaps you should start reading a textbook such as 'In vitro-in vivo
correlations' by David Young, John Devane and Jackie Butler, Plenum
Press, 1997, ISBN: 0306456001
There are at least 3 levels of correlation and you have to learn how
to establish discriminatory dissolution conditions for your
particular case. Gather also some of the many scientific papers in
the literature, through Medline or just Googling the keywords, akin
to your situation. The worst thing you can do is to take a recipe
from someone without a proper rationale.
--
Luis M. Pereira, Ph.D.
Assistant Professor, Biopharmaceutics and Pharmacokinetics
Massachusetts College of Pharmacy and Health Sciences
179 Longwood Ave, Boston, MA 02115
Phone: (617) 732-2905
Fax: (617) 732-2228
Luis.Pereira.-at-.bos.mcphs.edu
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)