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The following message was posted to: PharmPK
I have two high log P actives with MW ~500. The compounds are not
soluble in aqueous buffers, but are soluble in organic solvents like
DMSO/DMA.
I would like to develop an LC-MS/MS analytical assay to measure these
compounds in mouse plasma. Any recommendations on a great contract
lab for analytical assay development would be appreciated.
Steve
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The following message was posted to: PharmPK
Hi,
I don't think you need to concern about this.
Since your working standar solutions will be prepared
in organic solvent such as 50% ACN/water. Then you
spike you working standards into plasma. Plasma
behaves like a detergent, it won't give your any
problem in plasma if you have soubility issue in
water.
Xiaodong
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The following message was posted to: PharmPK
Dear Steve -
Advion
http://www.advion.com/
Charles Rivers Laboratory in Massachusetts
http://www.criver.com/preclinical_services/laboratory_services/
bioanalysis.h
tml
Regards,
Krys
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