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The following message was posted to: PharmPK
I'm design the pharmacokinetic profile of new compound
in rats whose intravenous dose in rats is 10 mg/kg. I
have a question regarding non-compartmental modeling.
In this plasma profile, there is a fast decrease of
concentration levels in 15 minutes what results in
very large AUC comparing AUMC. So, MRT (AUMC/AUC) is
very small, as well as Vdss. I think should have an
alternative to calculate MRT and Vdss for this case,
because AUMC neglects profile initial datas (Ct*t vs,
so Cpo*to=0). A two compartment open model was used to
fit the data showing MRT and Vdss very different/large
what I think to be correct.
Any help I would appreciate.
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